Of course, it only really runs well if your system is compatible so be prepared with a backup of your current operating system. That makes Bliss a super unique emulator if you can make it through the steps to the end. The USB installation method is even more complicated, but it lets your computer actually run Android natively from boot. As a VM install, the process is fairly simple, if tedious. This is definitely a power user option and not recommended for simple.
However, it can also just flat run on your computer through a USB stick. It works as an Android emulator for PC via virtual machine. Bliss is something a little bit different.